Reserpine Reserpine Sekolah Alam Shah Category="Alkaloids"Category="Antipsychotics"Category="Indole compounds"

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Reserpine
methyl-11,17α-dimethoxy-18β-[(3,4,5-trimethoxybenzoyl)
oxy]-3β,20α-yohimban-16β-carboxylate[:Reserpine}}#endnote_iupac]
CAS number
50-55-5		ATC code
C02AA02
Chemical formulaC33H40N2O9
Molecular weight608.679 g/mol
Bioavailability?
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Reserpine is an Indole Alkaloid[:Reserpine}}#endnote_indole-alkaloid] Antipsychotic and Antihypertensive drug known to irreversibly bind to storage vesicles of neurotransmitters such as Dopamine, Norepinephrine, and Serotonin.[:Reserpine}}#endnote_veterinary1] This leads to depletion of the neurotransmitters and subsequent depression in humans.

History

Reserpine was isolated in 1952 from the dried root of Rauwolfia serpentina (Indian Snakeroot),[:Reserpine}}#endnote_mercksource] and introduced in 1954, two years after Chlorpromazine.[:Reserpine}}#endnote_history1] Reserpine almost irreversibly blocks the accumulation of noradrenaline and dopamine into synaptic vesicles by inhibiting the Vesicular Monoamine Transporters (VMAT). [Schuldiner, S. et al. J. Biol. Chem. 1993 (268:1) 29-34]

References

  1.   アルカロイド (Alkaloids) (T-Z) 25 November 2004.
  2.   "Indole Alkaloids" Major Types Of Chemical Compounds In Plants & Animals Part II: Phenolic Compounds, Glycosides & Alkaloids. Wayne's Word: An On-Line Textbook of Natural History. 2 May 2005. Accessed 1 September 2005.
  3.   Forney, Barbara. Reserpine for Veterinary Use Wedgewood Pharmacy. 2001-2002.
  4.   Rauwolfia Dorlands Medical Dictionary. Merck Source. 2002.
  5.   Lopez-Munoz F, Bhatara VS, Alamo C, Cuenca E. "[Historical approach to reserpine discovery and its introduction in psychiatry]" [Article in Spanish] Actas Esp Psiquiatr.'' 2004 Nov-Dec;32(6):387-95. PMID 15529229 Fulltext in English and Spanish