Psychosurgery should not be confused with Neurosurgery, though they may seem similar; neurosurgery is surgery intended to treat or alleviate neurological disorders, which may or may not manifest mental illnesses as symptoms. Psychosurgery should also not be confused with the practice of Psychic surgery-surgery purportedly performed by paranormal means.
The first systematic attempts at human psychosurgery occurred from 1935, when the neurologist Egas Moniz teamed up with the surgeon Almeida Lima at the University of Lisbon to perform a series of prefrontal leucotomies-a procedure severing the connection between the prefrontal cortex and the rest of the Brain. This procedure is commonly called a "lobotomy". "Lobotomy" literally means "cutting through a lobe [of the brain]" and should not be confused with "lobectomy", which means "removal of a lobe [of the brain]". "Leucotomy" means "cutting through the white matter [of the brain]". The term "White matter" refers to the parts of the brain which carry signals between various other parts of the brain and nervous system.
Moniz and Lima claimed fair results, especially in the treatment of depression, although about 6% of patients did not survive the operation, and there were often marked and adverse changes in the patients' personality and social functioning. Despite the risks the process was taken up with some enthusiasm, notably in the U.S., as a treatment for previously incurable mental conditions. Moniz received a Nobel Prize in 1949.
The initial criteria for treatment were quite steep-only a few conditions of "tortured self-concern" were put forward for treatment. Severe chronic anxiety, depression with risk of Suicide and incapacitating Obsessive-compulsive disorder were the main symptoms treated. The original leucotomy was a crude operation and the practice was soon developed into a more exact stereotactic procedure where only very small lesions were placed in the Brain.
The procedure was popularised in the United States when Walter Freeman invented the "ice pick lobotomy" procedure, which literally used an ice pick and Rubber mallet instead of the standard surgical Leukotomy. Leaving no visible scars, the ice pick lobotomy was heralded as a great advance in "minimally invasive" surgery, and was eventually done under only local anaesthesia.
In a minimally invasive procedure, Freeman would hammer the ice pick into the skull just above the tear duct and wiggle it around. Between 1936 through the 1950s, he advocated lobotomies throughout the United States. Such was Freeman's zeal that he began to travel around the nation in his own personal van, which he called his "lobotomobile", demonstrating the procedure in many medical centres. He reputedly even performed a few lobotomies in hotel rooms.
Freeman's advocacy led to great popularity for lobotomy as a general cure for all perceived ills, including misbehaviour in children. Ultimately between 40,000 and 50,000 patients were lobotomised. A follow-up study of almost 10,000 patients claimed 41% were "recovered" or "greatly improved", 28% were "minimally improved", 25% showed "no change", 4% had died, while only 2% were made worse off (Tooth, et al. 1961). Lobotomies gradually became unfashionable with the development of antipsychotics and are no longer performed. The era of lobotomy is now generally regarded as a barbaric episode in psychiatric history.
It is possible that some patients did benefit from the more precise psychosurgery, but there was a strong division amongst the medical profession as to the viability of the treatment and concern over the irreversible nature of the operation and the extension of the surgery into the treatment of unsuitable cases (drug or alcohol dependence, sexual disorders, etc). Whatever the truth, psychosurgery was offered in only a few centres, and by the 1960s the number of operations was in decline. The signal improvements in Psychopharmacology and behaviour therapy gave the opportunity for more effective and less-invasive treatment.
Thus, the efficacy of psychosurgery was often related to changes in personality and reduced spontaneity (this included making the person quieter and lowering their sex drive). Certain processes related to Schizophrenia are also believed to occur in the frontal lobe, and may explain some success. However, certain types of inappropriate behaviours increased as a function of reduced impulse control (in some respects they became more childlike). Further, it decreased their ability to function as a member of the community by reducing their problem solving and planning abilities and making them less flexible and adaptive. It usually had no impact on IQ except with respect to problem solving.
Today, lobotomy is very infrequently practised. It may be a treatment of last resort for OCD sufferers, and may also be used for people suffering chronic pain. In the latter case, the surgery does not act on the perception of pain, but leads to a lack of concern about the pain. The procedure usually involves a 2-3cm lesion in the Cingulum near the Corpus callosum. The efficacy is not high, with improvement in 5 of 18 patients (Baer et al., 1995). Lobotomy is no longer used as a treatment for Schizophrenia.