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1543
Events- Japanese receive first firearms from shipwrecked Portuguese
- Indians in Spanish colonies are announced free against the wish of local settlers
ScienceBirths - January 18 - (baptized) - Alfonso Ferrabosco, Italian composer (died 1588)
- January 31 - Tokugawa Ieyasu, Japanese shogun (died 1616)
- February 15 - Charles II, Duke of Lorraine (died 1608)
- February 16 - Kano Eitoku, Japanese painter (died 1590)
- April 1 - François de Bonne, duc de Lesdiguières, Constable of France (died 1626)
- September 14 - Claudio Aquaviva, Italian Jesuit (died 1615)
- Thomas Deloney, English novelist and balladist (died 1600)
- Domenico Fontana, Italian architect (died 1607)
- Sonam Gyatso, 3rd Dalai Lama, first Dalai Lama
- Giovanni Maria Nanino, Italian composer (died 1607)
- François Pithou, French lawyer and author (died 1621)
- Chaim Vital, rabbi and mystic (died 1620)
- Federigo Zuccaro, Italian painter (died 1609)
Deaths - January 3 - Juan Rodríguez Cabrillo, Portuguese explorer (born 1499)
- January 9 - Guillaume du Bellay, French diplomat and general (b. 1491)
- February 21 - Ahmad Gragn, Imam of Adal (killed in battle)
- May 24 - Nicolaus Copernicus, Polish astronomer (born 1473)
- July 19 - Lady Mary Boleyn, mistress of Kings Francis I of France and Henry VIII of England (born 1500)
- September 20 - Thomas Manners, 1st Earl of Rutland (born 1492)
- Georg, Margrave of Brandenburg-Ansbach (born 1484)
- Polidoro Caldara da Caravaggio, Italian painter (born 1492)
- Baccio D'Agnolo, Florentine woodcarver (born 1460)
- Sebastian Franck, German freethinker (born 1515)
- Hans Holbein the Younger, German artist
- Margaret Lee, sister of poet Thomas Wyatt (born 1506)
- Francesco da Milano, Italian composer (born 1497)
- Sultan Quli Qutb Mulk, founder of the Qutb Shahi dynasty of Golconda
- Francesco Spiera, Protestant Italian jurist (born 1502)
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